Monday, April 9, 2007
Scottish Scientists Develop "Spray-On Computers" for Healthcare
Speckled computing - some of the most advanced computing technology in the world - is currently being researched and developed by a group of Scottish experts.
The individual appliances, or 'specks', will form networks that can be programmed like ordinary computers.
Spraying them directly onto a person creates the ability to carry out different tests at the same time, for example muscle movement and pulse rate. This allows a complete picture of the patient's condition to be built up quickly.
The computing innovation, being developed by scientists at Edinburgh, Glasgow, St Andrews and Strathclyde universities, will be displayed at the Edinburgh International Science Festival next Friday as part of a talk by Damal Arvind, leading speckled computing professor and director of the Scottish consortium.
Arvind said: "This is the new class of computing: devices which can sense and process the data they receive. They also have a radio so they can network and there's a battery in there as well, so they are entirely self-powered.
Sunday, April 8, 2007
Self Pap Smears??
Sure, we here at Medgadget are big fans of patients doing self-exams. Self breast exams and self testicular exams are excellent ways for patients to take their health into their own hands (bad pun intended). But doing your own pap smear? Will the kit come w/ a speculum and an angled mirror? No...there's just nothing good that can come from this.
Women who forgo screening for cervical cancer may be more inclined to participate in such programs if they're provided with a kit to obtain cervical samples at home, Dutch investigators report.
It's estimated that 28 percent of women in the Netherlands do not participate in cervical screening programs. Dr. Chris J. L. M. Meijer from VU University Medical Center, Amsterdam, and colleagues wanted to see if such women would agree to testing if they could provide samples without going to a clinic.
As reported in the International Journal of Cancer, 2,546 women who had not undergone regular cervical screening were mailed a self-sample kit. It included a small brush for collecting a cervical specimen, a collection tube, easy-to-follow instructions and a padded envelope for returning the sample to the lab. There it would be tested for human papillomavirus (HPV), which is the cause of nearly all cases of cervical cancer.
The rate of high grade pre-cancer detected in the self-sampling responders (1.67 percent) was significantly higher than in the other group (0.97 percent).
"Importantly," the researchers say, the costs of detecting one such lesion via self-sampling "are in the same range as those calculated for conventional ... screening."
Furthermore, they calculate that if the strategy was extended to the entire Netherlands, self-sampling could result in the early detection of 1,085 extra pre-cancerous lesions, "leading to roughly 100 cervical cancers being prevented or detected earlier."
Hmmm...maybe we spoke too soon...apparently Dutch women are very comfortable taking their own cervical samples. As always, our female fans, we need your help on this one: Would ya', Could ya', Should ya'?
Wednesday, March 28, 2007
Novel Antimicrobial Peptide Discovered
"Antibiotics are now under threat because of the explosion in antibiotic-resistant bacteria. A third of all deaths on this planet are the result of infection so there is an urgent need to create new therapies," says Robert Hancock, principal investigator and Canada Research Chair in Pathogenomics and Antimicrobials. "The beauty of this peptide is that it acts on the host to trigger a protective response and doesn't act on bacteria directly. That means it's unlikely bacteria will become resistant to it."
The team found that a peptide, or chain of amino acids, they have dubbed innate defense regulator peptide (IDR-1), can increase innate immunity without triggering harmful inflammation, and offer protection both before and after infection is present.
The discovery, in animal models, will be published March 25 in the journal Nature Biotechnology.
Researchers tested the peptide's effectiveness against Staphylococcus aureus including MRSA; a superbug called vancomycin-resistant Enterococcus (VRE); and Salmonella. In Staph and VRE infections, although bacteria were not completely eradicated, IDR-1 significantly reduced bacteria counts and mortality, when given either 24-48 hours before or four hours after infection began. In Salmonella, the peptide offered significant protection when administered prior to infection setting in.
Data showed that IDR-1 activates several signaling pathways to stimulate infection-clearing chemokines -- a chemical mediator that mobilizes immune response.
In addition, the peptide did not produce harmful inflammation and toxicity often seen when the immune system is stimulated and, in fact, actually reduced the potentially harmful septic response. Sepsis, a consequence of a ravaging inflammatory response associated with infection, kills as many as 200,000 annually.
Thursday, March 22, 2007
Trends in Tuberculosis Incidence: MMWR
TB is a nationally notifiable disease. Health departments in the 50 states and District of Columbia (DC) electronically report to CDC any TB cases that meet the CDC and Council of State and Territorial Epidemiologists case definition.§ Reports include the patient's race, ethnicity (i.e., Hispanic or non-Hispanic), treatment information, and drug-susceptibility test results if available. For this analysis, CDC calculated national and state TB rates (2) and rates for foreign-born and U.S.-born persons (3) and racial/ethnic populations (4) by using current U.S. census population estimates for the years 1993 through 2006.
In 2006, TB incidence rates in the 51 reporting areas ranged from 0.8 (Wyoming) to 12.6 (DC) cases per 100,000 population (median: 3.4 cases). Thirty states had lower rates in 2006 than 2005; 20 states and DC had higher rates (Table 1). In 2006, for the second consecutive year and the second time since national reporting began, approximately half of states (26 of 50) had TB rates of <3.5 per 100,000 (Figure 1); however, 11 of those 26 states had higher rates of TB in 2006 than in 2005. Seven states (California, Florida, Georgia, Illinois, New Jersey, New York, and Texas) reported more than 500 cases each for 2006; combined, these seven states accounted for 60% (8,259) of all TB cases.
Among U.S.-born persons, the number and rate of TB cases continued to decline in 2006. The U.S.-born TB rate was 2.3 per 100,000 population (5,924 or 43.3% of all cases with known origin of birth), representing a 7.0% decline in rate since 2005 and a 68.6% decline since 1993 (Figure 2).
Among foreign-born persons, the number of TB cases increased in 2006, but the rate decreased. The foreign-born TB rate in 2006 was 21.9 per 100,000 population, representing a 0.5% decline in rate since 2006 and a 35.8% decline since 1993. As the rate of decline in TB cases among foreign-born persons lagged behind the decline in TB cases among U.S.-born persons, the foreign-born to U.S.-born rate ratio increased 7.0%, from 8.9 in 2005 to 9.5 in 2006. In 2006, approximately half (55.6%) of TB cases among foreign-born persons were reported in persons from five countries: Mexico (1,912), the Philippines (856), Vietnam (630), India (540), and China (376).
In 2006, for the third consecutive year, more TB cases were reported among Hispanics than any other racial/ethnic population. Among persons with TB whose country of birth was known, 95.6% (3,126 of 3,269) of Asians, 74.7% (3,024 of 4,050) of Hispanics, 29.9% (1,110 of 3,712) of blacks, and 17.8% (427 of 2,404) of whites were foreign born. From 2005 to 2006, TB rates declined for all racial/ethnic minorities except American Indians/Alaska Natives and Native Hawaiians or Other Pacific Islanders¶ (Table 2).
Human immunodeficiency virus (HIV) contributes to the TB pandemic because immune suppression increases the likelihood of rapid progression from TB infection to TB disease. From 2005 to 2006, among TB cases with HIV status reported,** the percentage of TB cases with HIV infection decreased 4.4% (from 13.0% to 12.4%), but the percentage of TB cases with unknown HIV status increased 10.3% (from 28.7% to 31.7%).†† The decline in the percentage of TB cases with HIV infection might reflect incomplete reporting of HIV test results attributed to a lack of HIV testing or HIV reporting.
A total of 124 cases of multidrug-resistant TB (MDR TB)§§ were reported in 2005, the most recent year for which complete drug-susceptibility data are available.¶¶ The proportion of MDR-TB cases remained constant at 1.2% from 2004 (129 of 10,846 TB cases) to 2005 (124 of 10,662). In 2005, MDR TB continued to disproportionately affect foreign-born persons, who accounted for 101 (81.5%) of 124 MDR-TB cases.
The recommended length of drug therapy for most types of TB is 6--9 months. In 2003, the latest year for which treatment data are complete, 82.7% of patients for whom <1 year of treatment was indicated completed therapy within 1 year, below the Healthy People 2010 target of 90% (objective 14-12).
Tuesday, March 13, 2007
Time Travel
As if I needed a scientist to tell me that time travel can't be done.
This just iterates the old saying or rather definition of a doctor
A doctor is someone who know more and more about less and less until he knows everything about nothing
CJ
You Can't Travel Back in Time, Scientists Say
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While the idea makes for great fiction, some scientists now say traveling to the past is impossible.
There are a handful of scenarios that theorists have suggested for how one might travel to the past, said Brian Greene, author of the bestseller, “The Elegant Universe” and a physicist at Columbia University.“And almost all of them, if you look at them closely, brush up right at the edge of physics as we understand it. Most of us think that almost all of them can be ruled out.”
The fourth dimension
In physics, time is described as a dimension much like length, width, and height. When you travel from your house to the grocery store, you’re traveling through a direction in space, making headway in all the spatial dimensions—length, width and height. But you’re also traveling forward in time, the fourth dimension.
“Space and time are tangled together in a sort of a four-dimensional fabric called space-time,” said Charles Liu, an astrophysicist with the City University of New York, College of Staten Island and co-author of the book “One Universe: At Home In The Cosmos.”
Space-time, Liu explains, can be thought of as a piece of spandex with four dimensions. “When something that has mass—you and I, an object, a planet, or any star—sits in that piece of four-dimensional spandex, it causes it to create a dimple,” he said. “That dimple is a manifestation of space-time bending to accommodate this mass.”
The bending of space-time causes objects to move on a curved path and that curvature of space is what we know as gravity.
Mathematically one can go backwards or forwards in the three spatial dimensions. But time doesn’t share this multi-directional freedom.
“In this four-dimensional space-time, you’re only able to move forward in time,” Liu told LiveScience.
Tunneling to the past
A handful of proposals exist for time travel. The most developed of these approaches involves a wormhole—a hypothetical tunnel connecting two regions of space-time. The regions bridged could be two completely different universes or two parts of one universe. Matter can travel through either mouth of the wormhole to reach a destination on the other side.
“Wormholes are the future, wormholes are the past,” said Michio Kaku, author of “Hyperspace” and “Parallel Worlds” and a physicist at the City University of New York. “But we have to be very careful. The gasoline necessary to energize a time machine is far beyond anything that we can assemble with today’s technology.”
To punch a hole into the fabric of space-time, Kaku explained, would require the energy of a star or negative energy, an exotic entity with an energy of less than nothing.
Greene, an expert on string theory—which views matter in a minimum of 10 dimensions and tries to bridge the gap between particle physics and nature's fundamental forces, questioned this scenario.
“Many people who study the subject doubt that that approach has any chance of working,” Greene said in an interview . “But the basic idea if you’re very, very optimistic is that if you fiddle with the wormhole openings, you can make it not only a shortcut from a point in space to another point in space, but a shortcut from one moment in time to another moment in time.”
* Video: How to Time Travel!
Cosmic strings
Another popular theory for potential time travelers involves something called cosmic strings—narrow tubes of energy stretched across the entire length of the ever-expanding universe. These skinny regions, leftover from the early cosmos, are predicted to contain huge amounts of mass and therefore could warp the space-time around them.
Cosmic strings are either infinite or they’re in loops, with no ends, said J. Richard Gott, author of “Time Travel in Einstein's Universe” and an astrophysicist at Princeton University. “So they are either like spaghetti or SpaghettiO’s.”
The approach of two such strings parallel to each other, said Gott, will bend space-time so vigorously and in such a particular configuration that might make time travel possible, in theory.
“This is a project that a super civilization might attempt,” Gott told LiveScience. “It’s far beyond what we can do. We’re a civilization that’s not even controlling the energy resources of our planet.”
Impossible, for now
Mathematically, you can certainly say something is traveling to the past, Liu said. “But it is not possible for you and me to travel backward in time,” he said.
However, some scientists believe that traveling to the past is, in fact, theoretically possible, though impractical.
Maybe if there were a theory of everything, one could solve all of Einstein’s equations through a wormhole, and see whether time travel is really possible, Kaku said. “But that would require a technology far more advanced than anything we can muster," he said. "Don’t expect any young inventor to announce tomorrow in a press release that he or she has invented a time machine in their basement.”
For now, the only definitive part of travel in the fourth dimension is that we’re stepping further into the future with each passing moment. So for those hoping to see Earth a million years from now, scientists have good news.
“If you want to know what the Earth is like one million years from now, I’ll tell you how to do that,” said Greene, a consultant for “Déjà Vu,” a recent movie that dealt with time travel. “Build a spaceship. Go near the speed of light for a length of time—that I could calculate. Come back to Earth, and when you step out of your ship you will have aged perhaps one year while the Earth would have aged one million years. You would have traveled to Earth’s future.”
More about Time Travel
Sunday, February 18, 2007
House was right: Everybody lies
Lying to doctor can mean health risks
CHICAGO - There's an open secret in medicine: Patients lie.
understate how much they drink and overstate how much they exercise. They feign symptoms to get appointments quicker and ask doctors to hide the truth from insurance companies.
"Doctors have a rule of thumb. Whatever the patient says they're drinking, multiply it by three," said Dr. Bruce Rowe, a family doctor in suburban Milwaukee. "If they say two drinks a day, assume they have six."
Hippocrates, the father of medicine, is said to have warned his students around 400 B.C. that patients often dissemble when they say they've taken their medicine. TV's fictional Dr. Gregory House repeats the same message to his crack team: "Everybody lies."
But lying can lead to expensive diagnostic procedures and unneeded referrals to specialists. It also can have disastrous results.
"I definitely learned my lesson. I could have ended up in a coma," said Michael Levine, a 28-year-old financial adviser in Los Angeles, who lied to a specialist he saw for a wrist injury. Misguided pride, he said, kept him from mentioning the Xanax he was taking for anxiety. He didn't think the doctor needed to know.
"He wasn't my regular doctor. He was treating my wrist," Levine explained.
The doctor prescribed the pain reliever Vicodin and Levine took it on top of Xanax. The next few days vanished in a cloud of grogginess. Levine slept through ringing phones and alarms and woke up exhausted. His wrist pain was easing, but he could barely function. Eventually, he stopped the Vicodin, returned to the doctor and, under questioning, confessed.
"The doctor said, 'Why didn't you tell me? I never would have prescribed you that,'" said Levine, who now realizes how easily he could have overdosed and died. "For the future, I will always 'fess up."
Why do patients lie? The examination room itself is an environment that discourages honesty, said Los Angeles psychiatrist Dr. Charles Sophy.
"You're naked in a gown and you have a guy standing there clothed, with a coat on and there's all sorts of things in his pocket. And you're sitting there, basically naked ... that makes it hard to come clean," Sophy said. On top of that, the doctor may be rushed.
Researchers say patients often lie to save face. They want to be "good patients" in their doctors' eyes. But that's a misguided and risky practice. For example, a woman who doesn't want to admit she smokes and then is prescribed birth control pills is at greater risk for blood clots.
Some researchers estimate more than half of patients tell their doctors they're taking their medicine exactly as prescribed when they're not. In reality, they don't like the side effects, can't afford the pills or didn't understand the instructions.
A study by researchers at Johns Hopkins School of Medicine found a big gap between what patients said and what they did. Researchers looked at how patients with breathing problems used an inhaler equipped with a device that recorded the date and time of use and compared that with what the patients said.
Seventy-three percent of patients reported using the inhaler on average three times a day, but only 15 percent actually were using it that often. And 14 percent apparently deliberately emptied their inhalers before their appointments to make it look as if they were good patients.
Some doctors are seeking approaches that encourage more honesty. Dr. Zach Rosen, medical director of New York's Montefiore Family Health Center, asks his patients a series of questions to determine whether they're taking their medicine.
"I ask, 'What medications are you taking?' At first, I just want the names," he said. "They say, 'I'm taking X, Y or Z.' Then I'll say, 'That's great. How often are you taking that medication?' ... Then I'll say, 'Are you experiencing any problem in taking your medications?'"
Asking several questions takes more time. But the approach elicits better, more honest responses than a single question, Rosen believes.
Doctors also should avoid phrases that sound judgmental, said Nate Rickles, an assistant professor of pharmacy at Northeastern University. There's a big difference between "Why aren't you taking the medication as prescribed?" and "A number of my patients don't take their medication as prescribed and they do it for a variety of reasons. What do you think might be going on with you?"
When alcoholics seek detox treatment from Dr. Akikur Mohammad, an addiction specialist at the University of Southern California School of Medicine, they must tell him exactly how much they've been drinking so he can give them the right dose of medication to treat withdrawal.
"I tell them, 'You can lie to your friend, you can lie to your family members, but you came here for help and your report will determine the treatment plan. If I undermedicate you, you may have seizures and die,'" Mohammad said. Despite the warnings, patients still sometimes mislead him, he said.
Cyndi Smith, a 45-year-old Weight Watchers leader in suburban Chicago, admits her own lying past when it came to questions about her exercise and eating habits. She says she lied because she was fooling herself.
"You convince yourself of certain things and it becomes true, when in reality it's not," she said. If her doctor had questioned her more thoroughly, she says she might have told the truth.
"I think doctors could be a little more point-blank," she said. "And we need to be a little more honest."